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崔球
研究员
研究领域:1. Sheng Dong, Ya-Jun Liu, Haixia Zhou, Yan Xiao, Jian Xu, Qiu Cui*, Xinquan Wang*, Yingang Feng* (2021) Structural insight into a GH1 β-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int. J. Biol. Macromol. 170:196-206. 2. Fei Yan, Ren Wei*, Qiu Cui*, Uwe T. Bornscheuer, Ya-Jun Liu* (2021) Thermophilic whole-cell degradation of polyethylene terephthalate using engineered Clostridium thermocellum. Microbial Biotechnol. In press. 3. Xingzhe Yao†, Chao Chen†, Yefei Wang†, Sheng Dong, Ya-Jun Liu, Yifei Li, Zhenling Cui, Weibin Gong, Sarah Perrett, Lishan Yao, Raphael Lamed, Edward A. Bayer, Qiu Cui, Yingang Feng* (2020) Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. Sci. Adv. 6(43):eabd7182. 4. Sen Wang†, Chuanzeng Lan†, Zhuojun Wang, Weijian Wan, Huidan Zhang, Qiu Cui*, Xiaojin Song* (2020) Optimizing eicosapentaenoic acid production by grafting a heterologous polyketide synthase pathway in the Thraustochytrid Aurantiochytrium. J. Agric. Food Chem. 68(40):11253-11260. 5. Fei Xiao, Sheng Dong, Yang Liu, Yingang Feng, Huayue Li, Cai-Hong Yun, Qiu Cui, Wenli Li* (2020) Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase. J. Am. Chem. Soc. 142(37):16031-16038. 6. Sen Wang†, Chuanzeng Lan†, Zhuojun Wang, Weijian Wan, Qiu Cui*, Xiaojin Song* (2020) PUFA-synthase-specific PPTase enhanced the polyunsaturated fatty acid biosynthesis via the polyketide synthase pathway in Aurantiochytrium. Biotechnol. Biofuels. 13:152. 7. Jie Yang, Xiaojin Song, Lina Wang*, Qiu Cui* (2020) Comprehensive analysis of metabolic alterations in Schizochytrium sp. strains with different DHA content. J. Chromatog. B 1160:122193. 8. Xihui Zhang, Guang Yu, Xiaoyan Feng, Zhenqiu Li*, Bin Li*, Qiu Cui (2020) Ammonia-ethanol-water pretreatment of wheat straw for facilitating enzymatic saccharification integrated with the preparation of submicron lignin spheres. BioResources 15(3):5087-5109. 9. Guanglei Liu, Xiaoxue Zhao, Chao Chen, Zhe Chi, Yuedong Zhang, Qiu Cui, Zhenming Chi, Ya-Jun Liu* (2020) Robust production of pigment-free pullulan from lignocellulosic hydrolysate by a new fungus co-utilizing glucose and xylose. Carbohydr. Polym. 241:116400. 10. Guang Yu, Shiyue Liu, Xiaoyan Feng, Yuedong Zhang, Chao Liu, Ya-Jun Liu*, Bin Li*, Qiu Cui, Hui Peng* (2020) Impact of ammonium sulfite-based sequential pretreatment combinations on two distinct saccharifications of wheat straw. RSC Adv. 10:17129.
工作单位:青岛市
专家介绍
崔球,中国科学院青岛生物能源与过程研究所研究员,博士生导师,代谢物组学团队负责人,中科院"百人计划"。1997年四川大学生物工程学士,2004年中科院生物物理所生物化学与分子生物学专业博士。2004至2008年于美国威斯康星大学麦迪逊分校生物化学系从事代谢物组学研究,2009年全职回国工作并获中科院"百人计划"资助。近年来在Nature Biotechnology、Biotechnology for Biofuels、J. Biol. Chem、Proteins、Biochemistry等著名学术期刊发表论文数十篇。主要研究领域是基于代谢物组/代谢流组学的计算分析辅助能源微生物代谢工程设计、蛋白质结构功能研究。
主要成就
1. Sheng Dong, Ya-Jun Liu, Haixia Zhou, Yan Xiao, Jian Xu, Qiu Cui*, Xinquan Wang*, Yingang Feng* (2021) Structural insight into a GH1 β-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int. J. Biol. Macromol. 170:196-206. 2. Fei Yan, Ren Wei*, Qiu Cui*, Uwe T. Bornscheuer, Ya-Jun Liu* (2021) Thermophilic whole-cell degradation of polyethylene terephthalate using engineered Clostridium thermocellum. Microbial Biotechnol. In press. 3. Xingzhe Yao†, Chao Chen†, Yefei Wang†, Sheng Dong, Ya-Jun Liu, Yifei Li, Zhenling Cui, Weibin Gong, Sarah Perrett, Lishan Yao, Raphael Lamed, Edward A. Bayer, Qiu Cui, Yingang Feng* (2020) Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. Sci. Adv. 6(43):eabd7182. 4. Sen Wang†, Chuanzeng Lan†, Zhuojun Wang, Weijian Wan, Huidan Zhang, Qiu Cui*, Xiaojin Song* (2020) Optimizing eicosapentaenoic acid production by grafting a heterologous polyketide synthase pathway in the Thraustochytrid Aurantiochytrium. J. Agric. Food Chem. 68(40):11253-11260. 5. Fei Xiao, Sheng Dong, Yang Liu, Yingang Feng, Huayue Li, Cai-Hong Yun, Qiu Cui, Wenli Li* (2020) Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase. J. Am. Chem. Soc. 142(37):16031-16038. 6. Sen Wang†, Chuanzeng Lan†, Zhuojun Wang, Weijian Wan, Qiu Cui*, Xiaojin Song* (2020) PUFA-synthase-specific PPTase enhanced the polyunsaturated fatty acid biosynthesis via the polyketide synthase pathway in Aurantiochytrium. Biotechnol. Biofuels. 13:152. 7. Jie Yang, Xiaojin Song, Lina Wang*, Qiu Cui* (2020) Comprehensive analysis of metabolic alterations in Schizochytrium sp. strains with different DHA content. J. Chromatog. B 1160:122193. 8. Xihui Zhang, Guang Yu, Xiaoyan Feng, Zhenqiu Li*, Bin Li*, Qiu Cui (2020) Ammonia-ethanol-water pretreatment of wheat straw for facilitating enzymatic saccharification integrated with the preparation of submicron lignin spheres. BioResources 15(3):5087-5109. 9. Guanglei Liu, Xiaoxue Zhao, Chao Chen, Zhe Chi, Yuedong Zhang, Qiu Cui, Zhenming Chi, Ya-Jun Liu* (2020) Robust production of pigment-free pullulan from lignocellulosic hydrolysate by a new fungus co-utilizing glucose and xylose. Carbohydr. Polym. 241:116400. 10. Guang Yu, Shiyue Liu, Xiaoyan Feng, Yuedong Zhang, Chao Liu, Ya-Jun Liu*, Bin Li*, Qiu Cui, Hui Peng* (2020) Impact of ammonium sulfite-based sequential pretreatment combinations on two distinct saccharifications of wheat straw. RSC Adv. 10:17129.
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